The AUB GRADE center recently coordinated the RARE Best practices sickle cell disease pilot guideline project, which was funded by the European union. Dr. Elie Akl, Dr. Andrea Darzi and Ms. Rana Charide from the AUB GRADE center served as methodologists in the meeting that took place in Freiburg, Germany from the 16th to the 18th of June. Dr. Miguel Abboud, chair of the department of Pediatrics at AUB, and an internationally renowned expert in sickle cell disease served on the expert panel. The objective of this project was to assess whether the GRADe methodology could be used to develop guidelines for rare diseases. This project took place as part of a collaborative effort between RARE- Best practices, the MacGRADE Centre at McMaster University in Canada, the American University of Beirut (AUB) GRADE Center, and the German GRADE Center.