The AUB GRADE center was invited to deliver a workshop in Brazil on the development and adaptation of clinical practice guideline. The workshop was held on the 16th and 17th of November in Porto Alegre, Brazil. It was part of the conference Evidence in Health 2017 - The value of information: from science to decision-making organized by Hospital Moinhos de Vento and the Brazilian Ministry of Health. Twenty researchers from multidisciplinary backgrounds participated in the workshop. They included representatives from various universities, medical centers, non-governmental organizations and the ministry of health in Brazil. Participants were introduced to the development of practice guidelines using the GRADE methodology. Practical exercises were applied using the online guideline development tool (GRADEPro).