Canadian Guideline for Safe and Effective Use of Opioids for chronic non cancer pain guideline panel meeting. The guidelines project is funded by Health Canada and took place in Hamilton, Ontario on the 5th and 6th of January 2017.
Tuesday, January 10, 2017
Canadian Guideline for Safe and Effective Use of Opioids for chronic non cancer pain
Canadian Guideline for Safe and Effective Use of Opioids for chronic non cancer pain guideline panel meeting. The guidelines project is funded by Health Canada and took place in Hamilton, Ontario on the 5th and 6th of January 2017.
RARE- Best practices conference: use of GRADE in rare diseases
Dr. Andrea Darzi, the assistant director of the AUB GRADE center was invited to present on the "sickle cell disease pilot guidelines" at a conference in Rome, Italy on the 24th of November 2016. The RARE- Best practices project, funded by the European Union, organised the conference to disseminate its findings and offer a forum for discussing how this work could contribute to delivering better health decision-making and health policies for rare diseases. Dr. Darzi highlighted how the GRADE methodology can be used to develop and adapt guidelines for rare diseases. The AUB GRADE center took the lead in coordinating the "sickle cell disease pilot guidelines".
The American Society of Hematology (ASH) guidelines on management of venous thromboembolism
Dr. Andrea Darzi, the assistant director of the AUB GRADE center, contributed to the first panel meeting of the American Society of Hematology (ASH guidelines) project addressing the management of venous thromboembolism guideline effort. The meeting took place in the ASH headquarters in Washington D.C. from November 14 to 18, 2016 and included meetings for expert panels of five of the ten guidelines being developed as part of this project.
Tuesday, July 5, 2016
RARE Best Practices Sickle Cell Disease Pilot Guideline
The AUB GRADE center recently coordinated the RARE Best practices sickle cell disease pilot guideline project, which was funded by the European union. Dr. Elie Akl, Dr. Andrea Darzi and Ms. Rana Charide from the AUB GRADE center served as methodologists in the meeting that took place in Freiburg, Germany from the 16th to the 18th of June. Dr. Miguel Abboud, chair of the department of Pediatrics at AUB, and an internationally renowned expert in sickle cell disease served on the expert panel. The objective of this project was to assess whether the GRADe methodology could be used to develop guidelines for rare diseases. This project took place as part of a collaborative effort between RARE- Best practices, the MacGRADE Centre at McMaster University in Canada, the American University of Beirut (AUB) GRADE Center, and the German GRADE Center.
The AUB GRADE center organized an Expert Consultation meeting on Adapting the World Health Organization (WHO) Guidelines
The AUB GRADE center, directed by Dr. Elie Akl, organized an expert consultation meeting on the adaptation of WHO guidelines to the Eastern Mediterranean Region. The Two-day meeting took place on AUB campus, on the 30th and 31st of May 2016, and was in collaboration with the Eastern Mediterranean Regional Office (EMRO) of the World Health Organization (WHO). The expert panel included Drs. Kahled Younis and Fadi El- Jardali from AUB, international experts in guideline development as well as representation from WHO EMRO. It was also an opportunity for junior members and trainees at the AUB GRADE center to participate or observe a high level consultative meeting. This meeting built on an earlier expert consultation meeting organized by the WHO EMRO in november 2015 in Cairo, Egypt, and in which the AUB GRADE center was represented . It also took advantage of ongoing methodological work at the AUB GRADE center on the topic of guideline adaptation
Monday, July 4, 2016
The AUB GRADE center coordinated the Adaptation of Rheumatoid Arthritis Guidelines for the Eastern Mediterranean Region
The AUB GRADE center recently coordinated the Adaptation of Rheumatoid Arthritis Guidelines for the Eastern Mediterranean Region project. Three of the center team members, Dr. Elie Akl, Dr. Andrea Darzi and Ms. Manale Harfouche served as methodologists in the meeting that took place in Qatar from the 27th to the 29th of May 2016. Dr. Imad Uthman from AUB served as a member of the expert panel that included experts from 7 countries from the region, as well as from Canada, Denmark, and the United States. The objective of this project was to adapt the recently published American College of Rheumatology (ACR) Rheumatoid Arthritis (RA) guidelines to the Eastern Mediterranean Region. The project was a collaborative effort between the Weill Cornell Medical College in Qatar represented by Dr. Thurayya Arayssi, the Middle East Rheumatoid Arthritis Consortium (MERAC), and the American University of Beirut (AUB) GRADE Center. The project received funding from both the Qatar National Research Fund and Weill Cornell Medical College in Qatar.
Monday, June 20, 2016
New GRADE working group guidance on assessing risk of bias associated with missing participant outcome data
The GRADE working group has recently adopted guidance for assessing the risk of bias
associated with missing participant outcome data across an entire body of
evidence. This post summarizes the guidance, provides a background, relevant
references, and links to excel documents with calculators to facilitate the use
of the guidance.
The Guidance
·
Start with a primary meta-analysis using a
complete case analysis (i.e., excluding those with missing data)
·
Then conduct sensitivity meta-analyses imputing,
in each study, data for those with missing data, and then pooling across
studies.
o
For binary outcomes: we suggest use of
“plausible worst case” in which review authors assume that those with missing
data in treatment arms have proportionally higher event rates than those
followed successfully.
o
For continuous outcomes: use imputed mean values
from other studies within the systematic review, and the standard deviation
from the median standard deviations of the control arms of all studies. For meta-analyses in which investigators have
used different instruments to address the same construct, convert all scores to
standardized mean difference (SMD) or to the units of a selected reference
instrument.
·
If the results of the primary meta-analysis are
robust to the most extreme plausible assumptions, do not rate down quality of
evidence for risk of bias due to missing participant outcome data.
·
If the results of the primary meta-analysis are not
robust to the most extreme plausible assumptions, consider rating down quality
for risk of bias.
References
Links to MPD
assumptions calculators
Binary variables:
A freely downloadable Excel document to determine the numerators and
denominators to be used for each trial included in the metaanalysis according
to the selected assumption: https://www.dropbox.com/s/opstwgm45qiq57k/Assumptions%20about%20MPD%20v5.xls?dl=0
Continuous variables:
A freely downloadable Excel document to determine the means and SDs to be used
for each trial included in the meta-analysis according to the selected
assumption per strategy:
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